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Cambridge Core - Cell Biology and Developmental Biology - Key Experiments in Practical Developmental Biology - edited by Manuel Marí-Beffa.
Table of contents
- Why should we engage in Developmental Biology?
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- Cell biology and developmental biology | Cambridge University Press
- Key Experiments in Practical Developmental Biology
In particular, we strongly believe that undergraduates and graduate students, young and consolidated investigators from our region will greatly benefit from the direct interaction with American leader scientists in the C. The meeting is an excellent opportunity for American labs to get an integrated and updated view on C. It will encourage discussion and future collaborations among the participants, which could strengthen collaborations and training for Latin-American labs. We just had a great meeting in Buenos Aires to cap the end of October, and it really was the confirmation of Spring.
A great deal of cutting-edge and exciting science was discussed, showing how vibrant and alive the LASDB is, and we look forward with anticipation to the next meeting, in two years time.
Why should we engage in Developmental Biology?
This time there was a record of participation, and most to those attending were students, who discussed their work at length in the poster sessions. Already, many people how attended as students in the first LASDB meetings are now researchers, demonstrating the positive effect that the LASDB meetings and associated courses have had over its sixteen years of existence.
We hope to continue on all those trends in the future, bringing ever more first rate science and students and PIs together, expanding developmental biology in the region, in an ever growing virtuous circle. Kudos to this last meeting organizers, and to the bright future of developmental biology in the region. As president of the LASDB, I really hope to continue all these positive trends, and greatly appreciate the confidence deposited in me. Juan Riesgo-Escovar.
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Rosario, Argentina. The course will focus on the molecular processes controlling growth and development in multicellular organisms with an emphasis on the mechanisms controlling gene expression.
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Theoretical and practical modules of the program will show modern views and approaches to developmental biology and span a variety of model organisms including plants and animals. Extended deadline August New edition of the Quintay Dev Biol Course! The course is aimed for advanced graduate students and postdoctoral fellows who seek a broad view of the modern issues of Developmental Biology and consists of intensive laboratory work and lectures.
Deadline: 28th August Travel fellowships will be available. Twitter: DevBioQuintay. Facebook: DevBio Course Quintay. The program gives these individuals an opportunity to further their scientific knowledge by promoting exchange and collaboration between investigators in the United States and Latin America resulting in advances in research in Latin America. Applications must be submitted electronically by noon EST on Sept. June 2-July 15, Application deadline: February 1, The course, held each summer at the Marine Biological Lab at Woods Hole, is an intensive six-week laboratory and lecture course for graduate students, postdoctoral fellows, and senior researchers who seek a broad view of the modern issues of developmental biology and the experimental approaches used to address these ongoing questions.
Mechanisms on Development, Latin American issue, There has been enormous progress of Dev Biol in recent years. A rise in the number of papers published in Latin America, including those comprised in this special issue, alongside the increasing number of young scientists choosing to establish their laboratories in Latin America demonstrates an exciting progress. This workshop is intended to expose young Latin American scientists to cutting edge work done by colleagues around the world in the area of genomics and gene expression regulation.
To provide a wide diversity of models and mechanisms, we have selected speakers working on animal, plant and microbial systems and have strived to balance this diversity in the sessions. We provide ample time for discussion of speakers with young investigators at poster sessions and during our field activity. For the latter event, we will travel to a site in the Atacama Desert where scientists of the CGR are carrying out a year long project aimed at characterizing the genomes of desert plants, animals and soil microorganisms.
This Course aims at training a selected group of students, postdocs and junior investigators in theoretical and practical aspects of in vivo microscopy and strategies for the visualization and manipulation of forces in developing tissues. Topics: Optics and in vivo imaging, image processing and analysis, cell and tissue mechanics, physical modelling, cell migration and tissue morphogenesis, fish embryo models zebrafish, killifish. EMBO Workshop. This Workshop will bring together a cross-disciplinary collection of researchers from cell and developmental biology, tissue biophysics and theoretical physics, with the overarching goal of understanding how cells build tissues across scales during development.
The scientific content will thematically progress from cellular mechanics, to mechanics of tissue morphogenesis, to the integration of mechanics with cell fate, and ending with addressing how cell fate and self-organization can be coupled in an emergent tissue. Selected abstracts will be chosen for short talks and presented during poster sessions.
Application period ends December 30th, Updated information can be found at the course webpage.
Universidad de Chile. Facultad de Ciencias. January , Interesados portular por email a Alexander Vargas, alexvargas uchile. Curso a carge de Rui Diogo. This is a fantastic place to be isolated in a relaxed environment that allowed participants to talk about science, creating a highly collaborative and friendly environment to exchange ideas. The aim of this conference was to bring developmental biologists from other parts of the world to encourage students interested in this topic to attend the congress. On the other hand, a large number of young researchers who have arrived in Mexico as newly hired researchers were invited with the idea that they had the opportunity to present their work and also to generate collaboration opportunities with foreign and national groups.
This congress brought together 35 experts, 16 which were nationals and 19 internationals. The talks were divided into 8 keynote and 27 short talks. We are happy to announce the reestablishment the LASDB Prize that is to be awarded to outstanding developmental biologists, which might have shown desirable but not essential an involvement or active interest in Latin American science. The Prize has been awarded only once by our Society to Roberto Mayor in and it is now our intention to reestablish the prize and select an awardee on a regular basis every two years.
Any of you can nominate a candidate. Nominations should consist of a short statement of support maximum 1 page A4 from the proposer, stating why the candidate is suitable for the prize. Self-nomination is not allowed.
Cell biology and developmental biology | Cambridge University Press
The Committee will select the awardee by December Thanking in advance and looking forward for nominations. LAZEN was born in , in an initially timid initiative by four LASDB-member researchers from Argentina, Brazil, Chile and Uruguay, that quickly grew to become a thriving and adaptable forum for all regional zebrafish researchers, well beyond developmental biology. The activity started with a full-time 7-day hands-on course, where some international instructors introduced a selected group of students to the current essential experimental approaches in zebrafish research, including CRISPR-based genome editing, transgenesis, optogenetics, techniques for cell and tissue labeling, confocal microscopy and live imaging.
Lectures were also interspersed among the practicals. Strategically positioned social activities helped to immediately generate a highly collaborative and friendly environment among students and instructors, who spent together more than 12 hours a day. The meeting was short 2 days but intensive, with the participation of all the instructors and several other invited speakers, in a perfect balance of regional and international researchers, as well as covering an ever-growing diversity.
The goals of this meeting are to foster the scientific interaction in Argentina, promote the participation of young researchers and students, and the collaboration between groups.
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The maintenance of life and the capability to reproduce do not necessarily ensure that higher brain functions have developed normally and are functional in organisms raised in space see specific systems below. This would be. A major focus for space experiments should therefore be to maintain animals through successive generations, followed by detailed analyses to determine whether deficiencies detected are produced routinely.
During the past 10 years fruitflies 23 and nematodes 24 have been grown successfully in microgravity through more than one generation with no significant developmental abnormalities. Although further repetition of the experiments in flies might be necessary because some abnormalities were observed, these results basically indicate that no major developmental process in these simple organisms critically depends on gravity.
There are no comparable results with vertebrate animals, and such experiments should have high priority. The zebrafish, the current favorite of developmental geneticists for performing studies in lower vertebrates, may be difficult to rear in space because of its finicky environmental requirements. But the medaka fish, which is the favorite of the developmental biology community in Japan, may be more suitable for this experiment. In terms of avian development, some efforts have been made to grow chick or quail embryos in space, but these have been unsuccessful when embryos were brought into space during the earliest stages.
Key model organisms should be grown through two complete life cycles in space to determine whether there are any critical events during development that are affected by space conditions. Because no critical effects have been seen in model invertebrates, the highest priority should be given to testing vertebrate models such as fish, birds, and small mammals such as mice or rats.
If developmental effects are detected, control experiments must be performed on the ground and in space, including the use of a space-based 1-g centrifuge, to identity whether gravity or some other element of the space environment induces the developmental abnormalities. Neurobiologists working on space research are concerned about whether that part of the vestibular system that is sensitive to gravity can develop in microgravity.
The vestibular sensory receptors that are sensitive to gravity are called, collectively, the otolith organs. This includes the utricle and saccule. A principal role of the vestibular system is to relay signals from the otoliths regarding linear acceleration, and from the semicircular canals regarding rotation or angular acceleration, to the brain in order to control the motor output of the extrinsic eye muscles and those muscles in the neck collic and body vestibulospinal concerned with posture and balance.
Another example is the development of the visual system, where activity in the retinal pathway influences the specification of the connections determining how visual information is processed in the cerebral cortex. Therefore, experiments should be planned to be carried out in space that will test the hypothesis that gravity itself plays a role in the development and maintenance of the components of the peripheral and central vestibular system. Structures whose development may depend at least in part on exposure to gravitational stimuli.
These reflex pathways include the vestibulo-ocular, vestibulospinal and vestibulocollic fibers whose pathways, connections, and development have been investigated most extensively within the last 10 years. For example, the gravity-driven otoliths function in producing basic postural adjustments by interacting with signals from the semicircular canals. As a consequence, there is a need to understand more about these basic topics through ground-based studies before evaluating the potential for space-based experiments. In addition, there is some evidence that the vestibular system plays a role in regulating the autonomic nervous system.
Moreover, how these connections develop is still not understood. The following experiments should be performed first in ground-based studies to identify appropriate experiments to be performed in space. Because in ovo rather than in utero experiments afford the possibility of manipulating the embryo, using an avian system is most appropriate.
Key Experiments in Practical Developmental Biology
Studies should be performed to identify the critical periods in vestibular neuron development, including proliferation, migration, differentiation, and programmed cell death. This information is essential to design and interpret subsequent flight experiments on the effects of microgravity on vestibular development. Vertebrate brains form and maintain multiple neural maps of the spatial environment, which provide distinctive, topographical representations of different sensory and motor systems. For example, visual space is mapped onto the retina in a two-dimensional coordinate plan.
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In the adult, the neural maps must be maintained in register so that appropriate perceptual and motor adjustments can occur. There are several reasons to suspect that gravitational stimuli may have special importance in the development and maintenance of space maps and neural tracts that act in position-sensing in mammalian brains.
Apparently this system of neural maps must have appropriate information regarding the location of the head in the gravitational field, and so it follows that the vestibular system must play a key. Thus, from a theoretical point of view, it can be predicted that important interactions must occur between sensory and motor systems on the one hand, and the vestibular system on the other.